Adiponectin Promotes Caspase-14 Expression in Normal Human Epidermal Keratinocytes
نویسندگان
چکیده
منابع مشابه
Cultured Normal Human Epidermal Keratinocytes
H]glucosamine has been used to label metabolically keratinocyte cell-surface glycoconjugates. The major labelled bands identified on sodium dodecyl sulphate/polyacrylamide gels had apparent molecular weights of greater than 250000, and 150000-80000. Most of these components were trypsin-sensitive, indicating that the label was protein-bound. Some of the labelled components were shown to be prot...
متن کاملInactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes
Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...
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The epidermis is a multilayered squamous epithelium in which dividing basal cells withdraw from the cell cycle and progressively differentiate as they are displaced toward the skin surface. Eventually, the cells lose their nucleus and other organelles to become flattened squames, which are finally shed from the surface as bags of cross-linked keratin filaments enclosed in a cornified envelope [...
متن کاملAdiponectin Upregulates Filaggrin Expression via SIRT1-Mediated Signaling in Human Normal Keratinocytes
BACKGROUND Filaggrin (FLG) is the major component of the epidermal granular layer and binds to and condenses the keratin cytoskeleton. FLG thus contributes to cell compaction and serves as a natural moisturizing factor by promoting unfolding and degradation into hygroscopic amino acids. Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and...
متن کاملinactivation of mitogen-activated protein kinase signaling pathway reduces caspase-14 expression in impaired keratinocytes
objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...
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ژورنال
عنوان ژورنال: Annals of Dermatology
سال: 2019
ISSN: 1013-9087,2005-3894
DOI: 10.5021/ad.2019.31.3.352